Trifluoroacetyl Chloride CAS 354-32-5: Key Features, Applications, and Toxicological Factors
ProcurenetShort description
Trifluoroacetyl Chloride (CAS: 354-32-5) is a highly reactive pharmaceutical grade compound with a molecular formula of C2ClF3O. Featuring exceptional utility in organic synthesis, it’s primarily employed for the production of trifluoroacetic acid and its derivatives. Caution is advised during handling due to its high toxicity on inhalation and risk of producing harmful gases on reaction with water, steam or under high heat. This non-flammable yet potentially explosive compound under extreme heat conditions serves an integral role in various industrial applications.
- CAS Number: 354-32-5
- Chemical Formula: C2ClF3O
- Main Applications: Synthesis of trifluoroacetic acid/derivatives
- Key Features: High reactivity, non-flammable, potential explosion hazard under high heat
- Toxicological Information: Highly toxic on inhalation, forms harmful gases on reaction
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Procurenet Team Tshim Sha Tsui
Hong Kong
3 years
Description
Overview of Trifluoroacetyl Chloride CAS 354-32-5
Trifluoroacetyl chloride, denoted by the molecular formula C2ClF3O, is a critical intermediate extensively employed in various organic synthesis reactions. It is characterized by a molecular weight of 132.5 g/mol and is recognized as a colorless, strongly irritating gas. Unique about this chemical compound is its noticeable electron-absorbing impact that intensifies its reactivity towards nucleophiles while simultaneously attenuating its basicity when contrasted with other analogs devoid of fluorine like CH3COCl.
Key Attributes of Trifluoroacetyl Chloride
- Produces toxic and corrosive gas when interacting with water or steam, through an exothermic reaction.
- Presents elevated corrosivity to a broad array of metals, promoting potential cracking and explosion risk under extreme heating scenarios.
- Non-combustible but exudes potent toxicity and irritation.
- Emanates harmful gases like carbon monoxide, hydrogen chloride, and fluoride during combustion.
Prominent Applications of Trifluoroacetyl Chloride
Trifluoroacetyl chloride, particularly in its pharmaceutical grade, is primarily employed in generating trifluoroacetic acid in addition to a spectrum of other derivatives.
Toxicological Profile of Trifluoroacetyl Chloride
- On the acute toxicity scale, inhalation exposure to trifluoroacetyl chloride led to a recorded LCLo of 35300ppb/6H in rat and mouse models, while guinea pigs showed an LC value greater than 35300ppb/6H.
Given its powerful toxic and irritative properties, stringent safety protocols must be strictly adhered to when handling trifluoroacetyl chloride.
