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Pharmaceutical-Grade Tetrahydrofuran (THF): A Prime Solvent for Industrial and Laboratory Use
ProcurenetShort description
Pharmaceutical-Grade Tetrahydrofuran (THF) is a highly efficient solvent, recognized for its utility in diverse industrial and laboratory applications. The chemical, denoted by the molecular formula C4H8O and CAS number 109-99-9, serves as a vital ingredient in the production of polymers and active pharmaceutical ingredients. Key features include:
- Versatile Reactivity: THF’s excellent miscibility allows seamless interaction with various organic compounds.
- Fast Evaporation: Facilitated by its low boiling point, THF ensures rapid evaporation rates.
- Critical for Drug Production: Its importance in the manufacture of medicinal drugs signifies its role in the pharmaceutical industry.
Due caution should be exercised while handling due to its reactive and flammable properties.
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Procurenet Team Tshim Sha Tsui
Hong Kong
3 years
Description
Pharmaceutical-Grade Tetrahydrofuran (THF): A Comprehensive Overview
Pharmaceutical-grade Tetrahydrofuran (THF), identified by its CAS number 109-99-9, is characterized by its versatility, volatility and exceptional solvency properties, particularly for high molecular-weight compounds. This transparent, volatile product has earned its reputation as an invaluable ingredient in various industrial and research applications. It serves a crucial role in a variety of processes, including chemical reactions, PVC production, synthesis of natural products and pharmaceuticals.
Key Features and Specifications
- Chemical Identity: Known by various synonyms like THF, Oxacyclopentane, Cyclotetramethylene oxide, and Diethylene Oxide. Its IUPAC name is Oxacyclopentane.
- Physical Attributes: THF's molecular formula is C4H8O and has a molecular weight of 72.11 g/mol. It carries a density of 0.8892 g/mL at room temperature.
- Behavioral Characteristics: It exhibits a boiling point of 65-66°C, a flash point of -17°C, and a melting point of -108.4°C. Measured LogP of THF is 0.54.
- Solubility: THF is soluble in water, with a solubility of 5.55g per 100 mL at 25°C.
- GHS Classification: Holds a classification of Flam. Liq. 2, Health Hazard 2, Acute Tox. 4.
- Precautionary Measures: THF may cause respiratory irritation and is harmful if swallowed. To handle, avoid breathing vapors and wear protective clothing. Store in a cool, well-ventilated place. If swallowed, immediately call a doctor or poison control center.
- Ecotoxicity: Possesses a fish LC50 of 1,100 mg/l- 48 h for Leuciscus idus.
- Carcinogenicity: As per the International Agency for Research on Cancer (IARC), it isn't classifiable as a carcinogen to humans (Group 3).
As a premium quality solvent, THF is indispensable in the creation of an array of products like resins, adhesives, and films. It plays a significant role in the pharmaceutical industry, establishing itself as a favorite among researchers and manufacturers alike.
Please note that while we have strived to provide comprehensive and accurate information about THF, it's recommended to consult Material Safety Data Sheet or local professional for detailed and safe handling instructions.
