Complement C5, Human - Native Glycoprotein for Immunology Research

Complement C5, Human

Complement C5 is a highly valuable protein sourced from human serum, specifically designed to meet the diverse needs of researchers and scientists in a wide range of applications. Complement C5 is a native glycoprotein that plays a crucial role in the body's immune system, specifically in the complement pathway. This pathway serves as an essential defense mechanism against pathogens, promoting inflammation, opsonization, and cell lysis.

Complement C5 consists of two non-identical subunits, denoted as (a) and (b), with molecular weights of approximately 120 kDa and 75 kDa, respectively. These subunits are intricately linked by disulfide bonds, ensuring the protein's stability and functionality.

Complement C5 has undergone rigorous testing to ensure its purity and quality. It has been certified to be free from HBsAg (Hepatitis B surface antigen), as well as antibodies to HIV (Human Immunodeficiency Virus) and HCV (Hepatitis C Virus), providing researchers with the utmost confidence when working with this product.

Key Features:

• CAS Number: 80295-53-0 - Allows for easy identification and traceability of the product.
• Composed of two non-identical subunits: The presence of two distinct subunits contributes to the protein's overall structure and function.
• Molecular weight: 120 kDa (a) and 75 kDa (b) - The different molecular weights of the subunits highlight their unique characteristics and roles.
• Linked by disulfide bonds: The disulfide bonds between the subunits ensure the protein's stability and proper folding.
• Tested negative for HBsAg, HIV, and HCV antibodies: Rigorous testing ensures the product's purity and eliminates potential concerns regarding viral contamination.

Applications:

• Immunology Research: Complement C5 can be used to investigate the role of complement proteins in immunological processes, such as inflammation, immune response regulation, and autoimmune diseases.
• Pharmaceutical Development: The understanding of complement proteins, including C5, has led to the development of targeted therapies for various diseases. Researchers can utilize Complement C5 to study the mechanisms behind complement-related diseases and develop novel therapeutic strategies.
• Drug Discovery: Complement proteins have emerged as potential targets for drug discovery. By studying Complement C5, researchers can explore its interactions with other molecules and identify potential inhibitors or enhancers of complement activity.
• Diagnostic Assays: Complement C5 can be used as a critical component in diagnostic assays to assess complement system activity and monitor its dysregulation in various diseases.

Precautions and Storage:

• Complement C5 should be handled by trained professionals with proper laboratory techniques to ensure safety and minimize the risk of contamination.
• Store Complement C5 at -20°C to maintain its stability and preserve its biological activity. Avoid repeated freeze-thaw cycles to prevent protein degradation.
• Before each use, verify the integrity of the product by conducting appropriate quality control tests specific to your research objectives. Use only if the product meets the required quality standards.
• For long-term storage, aliquot the protein into smaller working volumes to prevent multiple freeze-thaw cycles of the same vial.

Overall, Complement C5 is a high-quality and reliable protein that provides researchers with a valuable tool for investigating the intricate workings of the complement pathway and its involvement in various physiological and pathological processes. With its certified purity and rigorous testing, Complement C5 offers the confidence and assurance necessary for successful research and scientific advancement.