b-Secretase Human Recombinant | BACE1 | Memapsin-2

b-Secretase Human Recombinant

• Expressed in HEK 293 cells (C-terminal FLAG tagged)
• Extracellular domain
• 10,000 units/mg protein
• 90% (SDS-PAGE)
• Buffered aqueous solution

The b-Secretase Human Recombinant, also known as BACE1 or Memapsin-2, is a protein expressed in HEK 293 cells with a C-terminal FLAG tag. It exists in the extracellular domain and is available in a high concentration of 10,000 units per milligram of protein. The purity of this recombinant protein is 90%, as determined by SDS-PAGE analysis. It is supplied in a buffered aqueous solution for ease of use and stability.

Amyloid precursor protein (APP) and b-secretase (BACE1) are key players in the development of Alzheimer's disease. BACE1 is involved in the cleavage of APP, which generates the amyloid-beta peptide, a major component of amyloid plaques found in the brains of individuals with Alzheimer's disease. Understanding the binding reaction between APP and b-secretase can provide insights into the pathogenesis of this neurodegenerative disorder. The b-Secretase Human Recombinant is a valuable tool for studying this interaction.

Features:

• Expressed in HEK 293 cells with a C-terminal FLAG tag
• High purity of 90% (SDS-PAGE)
• Supplied in a buffered aqueous solution

Applications:

• Investigation of the binding reaction between amyloid precursor protein and b-secretase
• Study of the enzymatic activity of b-secretase in the cleavage of substrates
• Assessment of the inhibitory effects of compounds on b-secretase activity

The b-Secretase Human Recombinant, also known as BACE1 or Memapsin-2, is a versatile tool for researchers working on Alzheimer's disease and related fields. Its high purity and well-defined composition ensure reliable and reproducible results. The inclusion of a C-terminal FLAG tag allows for easy detection and purification of the recombinant protein. By using this recombinant protein, researchers can gain a deeper understanding of the molecular mechanisms underlying the development of Alzheimer's disease and potentially identify new therapeutic targets.

Please note that the b-Secretase Human Recombinant is provided for research purposes only and is not intended for therapeutic or diagnostic applications. The product code for this recombinant protein is S4195.