Anti-PABPN1 Antibody - High-Quality Affinity Isolated Antibody

Product Description: Anti-PABPN1 Antibody - High-Quality Affinity Isolated Antibody

Our Anti-PABPN1 Antibody is a high-quality affinity isolated antibody designed specifically for the detection and characterization of the PABPN1 (poly(A) binding protein, nuclear 1) protein. Produced in rabbits using a meticulous process of affinity isolation, this antibody offers exceptional specificity and sensitivity, ensuring reliable and reproducible results in various applications.

Product Details:

• Affinity Isolated Antibody, produced in rabbit: Our Anti-PABPN1 Antibody is carefully produced in rabbits, ensuring high specificity and sensitivity. Through a meticulous process of affinity isolation, this antibody has been purified to create a product of exceptional quality and consistency. This ensures reliable and reproducible results in various applications.
• Buffered Aqueous Glycerol Solution: For reliable and long-lasting stability, our Anti-PABPN1 Antibody is supplied in a buffered aqueous glycerol solution. This solution provides an optimal environment to preserve the antibody's activity and prolong its shelf life. The buffering system helps maintain the pH level, ensuring the antibody remains functional throughout storage and usage.
• Suitable for Immunoblotting: The primary application of our Anti-PABPN1 Antibody is immunoblotting. Immunoblotting, also known as Western blotting, is a widely used technique in molecular biology and protein analysis. It allows for the detection and characterization of specific proteins within complex samples. With its high affinity and specificity, our Anti-PABPN1 Antibody is an ideal tool for identifying and studying the PABPN1 protein.

Target: PABPN1 (poly(A) binding protein, nuclear 1)

Our Anti-PABPN1 Antibody specifically targets the PABPN1 protein, also known as poly(A) binding protein, nuclear 1. PABPN1 is a member of the PABP protein family, which plays a crucial role in mRNA metabolism and processing. PABPN1 is primarily localized in the nucleus and is involved in various cellular processes, including transcription, polyadenylation, and mRNA export.

The PABPN1 protein consists of a nuclear localization signal and a highly conserved RNA-binding domain. It functions by binding to the poly(A) tail of newly synthesized mRNA, promoting its stabilization, and protecting it from degradation. Additionally, PABPN1 is involved in the regulation of alternative splicing, modulating the expression levels of different protein isoforms.

Dysregulation of PABPN1 has been associated with various diseases, including oculopharyngeal muscular dystrophy (OPMD) and cancer. In OPMD, mutations in the PABPN1 gene lead to the formation of intranuclear inclusions, causing muscle weakness and degeneration. In cancer, altered expression levels of PABPN1 have been correlated with tumor progression and poor prognosis in certain types of malignancies.

Our Anti-PABPN1 Antibody provides a valuable tool for researchers studying the function and regulation of PABPN1. By specifically targeting this protein, it allows for the detection and characterization of PABPN1 in various biological samples. This antibody is particularly useful in immunoblotting experiments, enabling the identification and analysis of PABPN1 expression levels, post-translational modifications, and protein-protein interactions.