Zoniporide hydrochloride

Zoniporide hydrochloride is a remarkable chemical compound that has captured the attention of researchers and scientists across various fields. This selective inhibitor of NHE-1, with an impressive IC50 of 14 nM and over 150-fold selectivity versus other NHE isoforms, offers a unique and powerful tool for exploring the complexities of cellular processes and developing innovative solutions.

At the heart of Zoniporide hydrochloride's versatility lies its ability to modulate the activity of the sodium-hydrogen exchanger 1 (NHE-1), a critical membrane transporter involved in the regulation of intracellular pH and cell volume. By selectively inhibiting this isoform, Zoniporide hydrochloride demonstrates its potential to address a wide range of physiological and pathological conditions, from cardiovascular disorders to neurological diseases.

The compound's exceptional purity, standing at 98.93%, ensures reliable and consistent results in research and development endeavors. Its chemical formula, C17H17ClN6O, and molecular weight of 356.81 g/mol provide a clear identification and allow for precise integration into complex experimental designs.

Zoniporide hydrochloride's versatility extends beyond its primary function as an NHE-1 inhibitor. In in vivo studies, the compound has shown promising pharmacokinetic properties, with an AUC0-∞ of 0.07 μg h/mL and a half-life of 0.5 hours in rats. These findings suggest its potential for targeted therapeutic interventions, where its rapid action and selective inhibition can be leveraged to address specific physiological challenges.

Furthermore, Zoniporide hydrochloride's ability to dose-dependently reduce infarct size in open-chest anesthetized rabbits highlights its potential applications in the field of cardioprotection. By modulating the activity of NHE-1, this compound may offer new avenues for mitigating the damaging effects of ischemic events and improving patient outcomes.

To ensure the long-term stability and integrity of Zoniporide hydrochloride, it is recommended to store the powder at -20°C for up to 3 years or in a solvent at -80°C for up to 1 year. These storage conditions are crucial for maintaining the compound's purity and potency, enabling researchers to rely on its consistent performance throughout their investigations.

As you delve into the world of Zoniporide hydrochloride, you'll discover a wealth of resources and technical data to support your research endeavors. Explore the available literature, safety information, and application notes to unlock the full potential of this remarkable compound and drive your scientific discoveries forward.

Product Features

• Selective inhibitor of NHE-1 with an IC50 of 14 nM and >150-fold selectivity versus other NHE isoforms
• Purity of 98.93% ensures reliable and consistent results in research and development
• Chemical formula: C17H17ClN6O, molecular weight: 356.81 g/mol
• Promising pharmacokinetic properties in in vivo studies, with an AUC0-∞ of 0.07 μg h/mL and a half-life of 0.5 hours in rats
• Demonstrated ability to dose-dependently reduce infarct size in open-chest anesthetized rabbits, suggesting potential applications in cardioprotection
• Recommended long-term storage conditions: powder at -20°C for up to 3 years, in solvent at -80°C for up to 1 year

Product Specification

• CAS Number: 241800-97-5
• Product Name: Zoniporide hydrochloride
• Reference Number: TM-T21996