PF-05089771 Tosylate: A Potent and Selective Nav1.7 Blocker

Unlock the power of PF-05089771 tosylate, a groundbreaking voltage-gated sodium channel 1.7 (Nav1.7) blocker that holds immense potential for transformative research and development. This highly purified compound, identified by the CAS number 1430806-04-4, boasts a remarkable selectivity profile and a deep understanding of its mechanisms of action. Delve into the captivating world of this versatile chemical, and discover how it can unlock new frontiers in the realms of pain management, neurological disorders, and beyond.

At the heart of PF-05089771 tosylate lies its exceptional ability to selectively target the Nav1.7 sodium channel, a key player in the transmission of pain signals. With potent inhibitory activity against the 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, this compound stands out as a promising candidate for the development of innovative pain therapeutics. Its remarkable selectivity, demonstrated by its low nanomolar IC50 values, ensures a laser-sharp focus on the desired target, minimizing the risk of off-target effects and enhancing the potential for therapeutic efficacy.

Unparalleled Selectivity and Potency

PF-05089771 tosylate's selectivity extends far beyond the Nav1.7 channel, showcasing its remarkable precision. It exhibits a staggering 1,000-fold preference for half-inactivated over resting Nav1.7 channels, a unique feature that could unlock new avenues for targeted pain relief. Furthermore, it demonstrates a high degree of selectivity over other sodium channel subtypes (Nav1.1-1.6 and 1.8), as well as L-type calcium and potassium channels, ensuring a clean pharmacological profile.

The compound's potency is equally impressive, with IC50 values ranging from 11 to 33 nM for the various Nav1.7 splice variants. This exceptional level of potency, combined with its selectivity, positions PF-05089771 tosylate as a powerful tool in the quest to understand and modulate the complex mechanisms underlying pain perception and transmission.

Versatile Applications and Potential

The versatility of PF-05089771 tosylate extends far beyond its role as a Nav1.7 blocker. This compound holds immense promise in the realms of neurological research, where it can shed light on the intricate interplay between ion channels and neuronal signaling. Its ability to selectively target the Nav1.7 channel, a key player in pain pathways, opens up new avenues for the development of targeted pain therapies that could revolutionize the management of chronic and neuropathic pain conditions.

Moreover, PF-05089771 tosylate's potential applications extend to the field of material science, where its unique chemical properties may contribute to the development of advanced materials with enhanced performance characteristics. Its integration into novel polymer structures or coatings could lead to the creation of materials with improved thermal stability, mechanical strength, or other desirable properties.

Comprehensive Product Details

• CAS Number: 1430806-04-4
• Product Name: PF-05089771 tosylate
• Reference Number: TM-T7502
• Purity: 98%
• Chemical Formula: C18H12Cl2FN5O3S2·C7H8O3S
• Molecular Weight: 672.56 g/mol
• Color and Form: Solid
• Long-Term Storage: Store at low temperature; Powder: -20°C for 3 years | In solvent: -80°C for 1