Milnacipran-d5 HCl

Milnacipran-d5 HCl, with the CAS number 101152-94-7, is a highly specialized and deuterated active pharmaceutical ingredient (API) that holds immense potential for researchers and scientists in the field of pharmaceutical development. This compound, a deuterated version of the antidepressant drug Milnacipran, offers a unique opportunity to explore the impact of isotopic substitution on the pharmacokinetic and pharmacodynamic properties of this important therapeutic agent.

The introduction of deuterium atoms in the Milnacipran-d5 HCl molecule can lead to subtle yet significant changes in the compound's metabolic profile, potentially enhancing its therapeutic efficacy and safety. By understanding the effects of deuteration, researchers can gain valuable insights into the drug's mechanism of action, metabolism, and overall pharmacological behavior, ultimately paving the way for the development of more effective and targeted treatments for a range of neurological and psychiatric disorders.

This Deuterated API, with its molecular formula of C15H17D5N2O·HCl and a molecular weight of 251.38 g/mol, presents as a white to off-white solid. Its high purity, as specified in the Certificate of Analysis, ensures reliable and consistent results in research and development applications. The compound's unique chemical structure, characterized by the presence of five deuterium atoms, sets it apart from its non-deuterated counterpart, offering researchers a powerful tool to explore the nuances of drug metabolism and pharmacokinetics.

Key Applications

• Pharmaceutical Research: Milnacipran-d5 HCl serves as a valuable research tool in the development of novel antidepressant therapies. By studying the effects of deuteration on the compound's pharmacokinetic and pharmacodynamic properties, researchers can gain insights into optimizing drug dosing, improving therapeutic efficacy, and minimizing potential side effects.
• Metabolic Studies: The deuterated nature of Milnacipran-d5 HCl allows for the precise tracking of the compound's metabolic pathways and the identification of key metabolites. This information can be crucial in understanding the drug's mechanism of action, metabolism, and potential interactions, ultimately contributing to the design of more effective and safer therapeutic interventions.
• Analytical Techniques: The distinct isotopic signature of Milnacipran-d5 HCl makes it a valuable tool in analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Researchers can leverage the compound's deuterium labeling to develop sensitive and selective analytical methods for the quantification and characterization of Milnacipran and its metabolites in various biological matrices.

Product Specifications

• Molecular Formula: C15H17D5N2O·HCl
• Molecular Weight: 251.38 g/mol
• Color and Form: White to off-white solid
• Purity: As specified in the Certificate of Analysis
• Hazard Statements: H302, H312, H315, H319, H332
• Precautionary Statements: P261, P271, P280, P302+P352, P305+P351+P338

Storage and Handling

Milnacipran-d5 HCl should be stored refrigerated, as specified in the Certificate of Analysis, to maintain its stability and integrity. The container should be kept tightly closed in a dry and well-ventilated place. It is important to handle this compound with care, adhering to the appropriate safety precautions, as it is classified as harmful if swallowed, in contact with skin, or inhaled, and can cause skin and eye irritation.

Important Note