GNE-131: A Potent Inhibitor of Human Sodium Channel NaV1.7

Introducing GNE-131, a remarkable chemical compound that has captured the attention of researchers and scientists worldwide. This potent and specific inhibitor of the human sodium channel NaV1.7 (IC50: 3 nM) holds immense potential in the realms of pharmaceutical research and development. With its exceptional purity, unique chemical properties, and proven efficacy, GNE-131 is poised to unlock new frontiers in the pursuit of innovative therapies.

At the heart of GNE-131's allure lies its ability to selectively target the human sodium channel NaV1.7, a crucial player in the transmission of pain signals. By inhibiting this channel, GNE-131 demonstrates remarkable potential in the management of various pain-related conditions, offering hope for those seeking relief from chronic or neuropathic pain. This targeted approach, combined with the compound's high potency, sets the stage for the development of groundbreaking pain-relieving treatments.

Exceptional Chemical Profile

GNE-131 boasts an impressive chemical profile, with a purity of 99.59% and a molecular formula of C23H30N4O3S. Its density of 1.70 G/Cm3 and a molecular weight of 442.57 g/mol further contribute to its unique characteristics. Presented as a solid with a distinct color, GNE-131 is a meticulously crafted compound that meets the highest standards of quality and purity.

The compound's exceptional properties extend beyond its chemical composition. GNE-131 demonstrates moderate clearance in human liver microsomes, ensuring its stability and potential for effective in vivo application. Moreover, it displays excellent functional activity against the human NaV1.7 channel, with an IC50 value of just 0.003 μM, underscoring its potency and selectivity.

Versatile Applications

The versatility of GNE-131 extends far beyond its primary function as a sodium channel inhibitor. This remarkable compound has garnered attention from researchers across various disciplines, each seeking to harness its unique capabilities.

In the realm of pharmaceutical research, GNE-131 serves as a crucial building block in the synthesis of innovative drug candidates. Its ability to selectively target the NaV1.7 channel opens up new avenues for the development of pain-relieving therapies, potentially addressing a wide range of pain-related conditions, from neuropathic pain to chronic pain syndromes.

Beyond the pharmaceutical sector, GNE-131 also finds applications in the field of agrochemicals. Its chemical properties contribute to the synthesis of advanced crop protection agents, helping to safeguard agricultural yields and promote sustainable farming practices.

Comprehensive Storage and Handling

To ensure the long-term stability and integrity of GNE-131, meticulous storage and handling protocols are in place. For optimal preservation, the compound should be stored as a powder at -20°C for up to 3 years. If dissolved in a suitable solvent, GNE-131 can be stored at -80°C for up to 1 year.

When handling GNE-131, it is essential to adhere to standard laboratory safety protocols. This includes wearing appropriate personal protective equipment, such as gloves, lab coats, and eye protection, and working in a well-ventilated area. By following these guidelines, researchers can safely and effectively utilize GNE-131 in their various scientific endeavors.

Unlocking the Potential

GNE-131 stands as a testament to the power of scientific innovation and the pursuit of groundbreaking discoveries. As researchers delve deeper into the compound's capabilities, the possibilities for its application continue to expand, promising new breakthroughs in the management of pain and the development of cutting-edge therapeutics.

Embrace the potential of GNE-131 and embark on a journey of scientific exploration. Leverage its unique properties to drive advancements in your field, whether it's in the realm of pharmaceutical research, agrochemical development, or beyond