Carboxyrhodamine 110-PEG4-alkyne

Carboxyrhodamine 110-PEG4-alkyne is a versatile and highly specialized chemical compound that has garnered significant attention in the scientific community. This polyethylene glycol (PEG) derived linker is a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), a revolutionary approach in drug discovery and development.

At its core, Carboxyrhodamine 110-PEG4-alkyne is a meticulously crafted molecule that combines the power of rhodamine 110, a fluorescent dye, with a PEG4 linker and an alkyne functional group. This unique combination of features makes it an invaluable tool for researchers working in the fields of biochemistry, cell biology, and medicinal chemistry.

The rhodamine 110 moiety within the compound serves as a highly sensitive and selective fluorescent marker, enabling researchers to track and visualize the behavior of target proteins in complex biological systems. The PEG4 linker, on the other hand, provides a flexible and hydrophilic tether, facilitating the attachment of the compound to various biomolecules, such as proteins or small molecules, without compromising their functionality.

The alkyne group present in Carboxyrhodamine 110-PEG4-alkyne further enhances its versatility, as it can undergo click chemistry reactions, allowing for the efficient and site-specific labeling of biomolecules. This versatility makes the compound a powerful tool in the development of PROTACs, which rely on the selective degradation of target proteins to achieve their therapeutic effects.

PROTACs are a revolutionary approach in drug discovery, as they exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. By utilizing Carboxyrhodamine 110-PEG4-alkyne as a linker, researchers can create highly specific and potent PROTACs, opening up new avenues for the treatment of a wide range of diseases, from cancer to neurodegenerative disorders.

Product Features

• High purity (98%) for reliable and consistent results in research applications
• Unique combination of rhodamine 110, PEG4 linker, and alkyne group for versatile labeling and PROTAC synthesis
• Fluorescent properties of rhodamine 110 enable tracking and visualization of target proteins in complex biological systems
• PEG4 linker provides flexibility and hydrophilicity, facilitating the attachment of the compound to biomolecules
• Alkyne group allows for efficient click chemistry reactions, enabling site-specific labeling of biomolecules

Product Specifications

• CAS Number: 2055103-66-5
• Reference Number: TM-T14874
• Purity: 98%
• Density: 1.31 g/cm³
• Molecular Formula: C32H33N3O8
• Molecular Weight: 587.62 g/mol
• Color and Form: Solid

Long-term Storage

For optimal storage and preservation of Carboxyrhodamine 110-PEG4-alkyne, it is recommended to store the compound as a powder at -20°C for up to 3 years. If stored in a solvent, the recommended storage temperature is -80°C for up to 1 year.

In Vitro Applications

Carboxyrhodamine 110-PEG4-alkyne is a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs), a groundbreaking approach in drug