TAK-901 - Potent and Tight-Binding Aurora B Kinase Inhibitor - Product Overview

REF #: 3199770
Procurenet
Short description
  • TAK-901 is a potent and tight-binding Aurora B kinase inhibitor.
  • It has a purity of 98% (HPLC).
  • Composed of the chemical compound 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide.
  • Commonly referred to as SML2155, TAK-901, TAK 901, or by its CAS number 934541-31-8.
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

TAK-901 - Potent and Tight-Binding Aurora B Kinase Inhibitor

TAK-901 is a highly efficient and tightly-binding Aurora B kinase inhibitor designed to effectively inhibit the enzymatic activity of Aurora B, an important protein kinase involved in crucial cellular processes such as mitosis and cell division. With its exceptional quality and purity, TAK-901 ensures reliable and reproducible experimental results, making it an indispensable tool for researchers studying various aspects of cell division, mitosis, and cancer biology.

Key Features:

  • High potency: TAK-901 exhibits robust inhibitory activity against Aurora B kinase, making it an ideal tool for researchers studying the function of this kinase and its potential as a therapeutic target.
  • Tight binding: TAK-901 forms a strong and stable interaction with the active site of Aurora B kinase, resulting in prolonged and effective inhibition of its enzymatic activity.
  • High purity: TAK-901 is manufactured to have a purity of 98% as determined by high-performance liquid chromatography (HPLC). This ensures the absence of impurities that could potentially affect experimental results and ensures reliable and reproducible outcomes.
  • Broad applications: TAK-901 is widely employed in various applications, including research studies, drug discovery, pathway analysis, and target validation.

Product Overview:

TAK-901, with a purity of 98% (HPLC), possesses a unique chemical structure composed of the chemical compound 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide. This compound has shown exceptional inhibitory properties against Aurora B kinase. It is widely used in biomedical research, drug discovery, and preclinical and clinical studies.

Applications:

TAK-901 finds utility in several research areas and applications, including but not limited to:

  • Cell cycle regulation studies
  • Mitotic spindle assembly research
  • Investigation of mitosis inhibitors
  • Cancer research focusing on the inhibition of tumor cell proliferation
  • Studying the role of Aurora B kinase in chromosomal instability and aneuploidy
  • Development of potential anti-cancer therapies targeting Aurora B kinase

Synonyms and Identifiers:

TAK-901 is also known by the following synonyms and identifiers:

  • SML2155
  • TAK-901
  • TAK 901
  • CAS number: 934541-31-8

Handling and Storage:

When handling TAK-901, it is recommended to follow standard laboratory safety procedures, including the use of appropriate protective equipment such as gloves and safety glasses. Moreover, it should be stored at -20°C in a tightly-sealed container away from direct sunlight and moisture to maintain its stability and effectiveness.

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