Sodium 4-Phenylbutyrate - Highly Effective Anti-Neoplastic Agent

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Sodium 4-Phenylbutyrate – Highly Effective Anti-Neoplastic Agent and Transcriptional Regulator

  • Novel anti-neoplastic agent and transcriptional regulator
  • Highly effective in targeted cancer therapy
  • CAS Number: 1716-12-7
  • Synonyms: SPB, PBNa, 4PBA, BCKD Kinase Inhibitor I, BDK Inhibitor I
  • Find -567616 MSDS, related papers, technical documents, and similar products at 567616
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Sodium 4-Phenylbutyrate - Highly Effective Anti-Neoplastic Agent and Transcriptional Regulator

Sodium 4-Phenylbutyrate is a highly effective and versatile compound that serves as a novel anti-neoplastic agent and transcriptional regulator. With its unique properties, Sodium 4-Phenylbutyrate has gained recognition in various scientific fields for its potential in therapeutic applications.

Key Features:

  • Chemical Formula: C10H11NaO2
  • CAS Number: 1716-12-7
  • Synonyms: Sodium 4-Phenylbutyrate, SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BCKD Kinase Inhibitor I, Branched-Chain μ-Ketoacid Dehydrogenase Kinase Inhibitor I, BDK Inhibitor I


Sodium 4-Phenylbutyrate is a white crystalline powder with a molecular weight of 190.19 g/mol. Its chemical structure consists of a phenyl group attached to a butyric acid backbone. The sodium salt form enhances its solubility and bioavailability, making it a highly versatile compound for various applications.

Features and Benefits:

  • Anti-Neoplastic Agent: Sodium 4-Phenylbutyrate exhibits potent anti-cancer properties, making it an excellent candidate for use in oncology research and therapy. It has been shown to inhibit tumor cell growth and induce apoptosis in various cancer cell lines.
  • Transcriptional Regulator: Through its ability to modulate gene expression, Sodium 4-Phenylbutyrate acts as a transcriptional regulator. It can modify the epigenetic landscape and regulate key cellular processes, providing a unique avenue for investigating gene therapies and developing new treatment approaches.
  • Research Applications: Sodium 4-Phenylbutyrate has been extensively utilized in preclinical and clinical studies across a range of disciplines:
  • Oncology: Investigating its anti-cancer properties and potential for combination therapies.
  • Neurodegenerative Diseases: Exploring its neuroprotective effects and therapeutic potential for conditions such as Huntington's disease and amyotrophic lateral sclerosis (ALS).
  • Genetic Disorders: Studying the ability of Sodium 4-Phenylbutyrate to modulate gene expression and correct protein folding, with potential implications for genetic disorders like cystic fibrosis and lysosomal storage disorders.
  • Metabolic Disorders: Evaluating its role in restoring metabolic balance and treating conditions related to branched-chain amino acid metabolism.
  • Biological Activity: Sodium 4-Phenylbutyrate acts on various cellular targets and pathways, including:
  • Inhibition of histone deacetylase (HDAC): Modulating chromatin structure and gene expression patterns.
  • Inhibition of heat shock protein (HSP) 90: Affecting protein folding and stability.
  • Activation of the unfolded protein response (UPR): Regulating cellular stress and protein homeostasis.
  • Modulation of autophagy: Influencing cellular degradation processes.
  • Quality Control: Sodium 4-Phenylbutyrate undergoes rigorous quality control measures to ensure its purity, consistency, and reliability. Each batch is tested for chemical identity, composition, and contaminants to meet the highest quality standards.


Sodium 4-Phenylbutyrate holds immense potential across various research fields and therapeutic applications:

  • Oncology: Sodium 4-Phenylbutyrate can be used as a tool compound to investigate tumor biology, develop targeted therapies, and assess the efficacy of combination treatments.
  • Epigenetics and Gene Therapy: With its ability to modulate gene expression, Sodium 4-Phenylbutyrate offers a unique avenue for understanding and manipulating epigenetic marks, with implications for gene therapy and precision medicine.
  • Neurodegenerative Diseases: The neuroprotective properties of Sodium 4-Phenylbutyrate make it a promising candidate for developing new therapeutic strategies for neurodegenerative disorders.
  • Inborn Errors of Metabolism: Sodium 4-Phenylbutyrate has shown potential in restoring metabolic balance in various genetic disorders associated with aberrant amino acid metabolism.

As a trusted supplier of research reagents and chemicals, we provide Sodium 4-Phenylbutyrate of the highest quality to support your scientific investigations. Our product undergoes stringent quality control procedures, ensuring its purity and reliability for consistent results in your research endeavors.

Discover the potential of Sodium 4-Phenylbutyrate - a versatile compound with remarkable anti-neoplastic and transcriptional regulating properties. Explore its applications across oncology, epigenetics, neurodegenerative diseases, and metabolic disorders in your quest for scientific advancement.

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