Roscovitine: Potent Inhibitor of Cyclin-Dependent Kinases

REF #: 3199398
Short description

Roscovitine: Potent Inhibitor of Cyclin-Dependent Kinases

  • Purine derived inhibitor with a 98% purity level
  • Effectively inhibits cyclin-dependent kinases
  • Verified purity by TLC method
  • CAS number: 186692-46-6
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Roscovitine: Potent Inhibitor of Cyclin-Dependent Kinases

Roscovitine is a highly potent inhibitor of cyclin-dependent kinases, effectively blocking the activity of these kinases involved in cell cycle regulation and proliferation. Its selective inhibition ensures that other kinases are not affected, allowing for targeted inhibition and minimizing the risk of unwanted side effects. Derived from purines, important components of nucleic acids, Roscovitine's structure contributes to its effectiveness and specificity in inhibiting the target kinases. With a purity level of 98%, as determined by TLC, Roscovitine guarantees consistency and quality. Its CAS number, 186692-46-6, widely used in scientific research, accurately identifies and references the product.

Roscovitine Mechanism of Action

Roscovitine exerts its inhibitory effects by competitively binding to the ATP binding site of cyclin-dependent kinases, preventing phosphorylation of target proteins and interrupting cell cycle progression and cell division. This selective inhibition is attributed to Roscovitine's structural features and specific interactions with the target kinases. The purine-derived structure optimally binds to the ATP binding site of cyclin-dependent kinases while minimizing interactions with other kinases.

Benefits and Applications

  • Cancer research: Roscovitine shows promise as a potential anti-cancer agent, disrupting the uncontrolled cell division seen in cancer cells by inhibiting cyclin-dependent kinases.
  • Cell cycle studies: Widely used in cell cycle studies, Roscovitine helps researchers better understand the mechanisms underlying cell division and proliferation by investigating the roles of cyclin-dependent kinases in cell cycle regulation.
  • Neurological disorders: With its involvement in neuronal development and function, Roscovitine is explored as a potential therapeutic agent for neurological disorders like Alzheimer's disease and Parkinson's disease.
  • Virology research: In virology research, Roscovitine is used to study the effects of cyclin-dependent kinase inhibition on viral replication and maturation, as viruses often manipulate the host cell's cell cycle machinery.

Usage and Storage

  • Store Roscovitine in a cool and dry place, away from direct sunlight.
  • Handle Roscovitine with proper protective equipment, such as gloves and safety glasses, to avoid direct contact.
  • Use Roscovitine in a well-ventilated area to prevent inhalation of the product.
  • Follow good laboratory practices and any applicable safety regulations when using the product.

In conclusion, Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases. With its purine-derived compound structure and high purity level of 98%, Roscovitine offers great potential for further scientific exploration and therapeutic development. Its mechanism of action and specific interactions with target kinases make it an essential tool in cancer research, cell cycle studies, neurological disorders, and virology research.

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