(R)-PFI-2 - Histone-Lysine N-Methyltransferase Inhibitor

REF #: 3199775
Procurenet
Short description

This compound is a histone-lysine N-methyltransferase (HKMT) inhibitor that is featured in Gene Regulation research. It is known as (R)-PFI-2 and has a purity of 97% (HPLC).

Key features:

  • Selective fSML1408
  • (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride
  • 1627607-87-7
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

(R)-PFI-2 - Histone-Lysine N-Methyltransferase Inhibitor

(R)-PFI-2 is a highly potent and selective histone-lysine N-methyltransferase (HKMT) inhibitor. It is commonly used in Gene Regulation research due to its ability to modulate epigenetic mechanisms and regulate gene expression. With a purity of 97% (HPLC), this compound guarantees high-quality performance in various experiments and assays.

Chemical Formula and Structure

  • Chemical Name: (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
  • Molecular Formula: C24H27F4N3O3S
  • Molecular Weight: 519.55 g/mol
  • CAS Number: 1627607-87-7

Features and Benefits

  • High purity: (R)-PFI-2 is provided at a purity of 97% (HPLC), ensuring minimal impurities and reliable results.
  • Selective inhibitor: It selectively inhibits a specific histone-lysine N-methyltransferase, fSML1408, allowing for targeted and focused research on gene regulation.
  • Epigenetic modulation: By interfering with HKMT activity, (R)-PFI-2 enables researchers to study the impact of histone modifications on gene expression and cellular processes.
  • Gene Regulation research: The compound's specific mechanism of action makes it an ideal tool for investigating the role of histone methylation in gene regulation and epigenetics.

Applications

(R)-PFI-2 is widely used in various research applications, particularly in the field of Gene Regulation. Due to its unique properties and high potency, it plays a vital role in advancing understanding in the following areas:

  • Epigenetics and chromatin remodeling studies
  • Functional analysis of histone modifications
  • Identification and validation of histone methyltransferase targets
  • Drug discovery and development for epigenetic therapies
  • Investigation of cellular pathways regulated by histone methylation

Storage and Handling

Proper storage and handling of (R)-PFI-2 are essential to maintain its integrity and effectiveness:

  • Store the compound in a cool and dry place.
  • Avoid exposure to light, heat, or moisture.
  • Seal the container tightly after each use.
  • Handle the compound with appropriate protective measures, including gloves and goggles.
  • Dispose of any unused or expired (R)-PFI-2 according to local regulations.

Safety Information

(R)-PFI-2 is a research compound intended for laboratory use only. It should be handled by trained professionals in a controlled environment. Adhering to the following safety precautions is crucial:

  • Avoid direct contact with skin, eyes, and clothing. In case of contact, rinse thoroughly with water.
  • Use in a well-ventilated area or under a fume hood to minimize inhalation exposure.
  • Do not ingest or inhale the compound.
  • Wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles.

For detailed safety information and handling instructions, refer to the Safety Data Sheet (SDS) provided with the product.

Ordering Information

(R)-PFI-2 ((R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide) is available in a 97% purity HPLC grade. To order, please contact our sales team or visit our website for online purchase options.

Experience the power of (R)-PFI-2 in your Gene Regulation research today!

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