Prostaglandin D2 - Key Features, Uses, and Applications

REF #: 3199659
Short description

Prostaglandin D2

  • Major prostaglandin metabolite found in the brain
  • Important inflammatory mediator in mast cells
  • Used in various research studies and experiments
  • CAS Number: 41598-07-6
  • Synonyms: Prostaglandin D2, PGDu201au00c7u00c7
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Prostaglandin D2

Prostaglandin D2 (PGD2) is a major prostaglandin metabolite found in the brain and acts as an important inflammatory mediator in mast cells. It is commonly used in various research studies and experiments.

Key Features:

  • CAS Number: 41598-07-6
  • Synonyms: Prostaglandin D2, PGDu201au00c7u00c7

Prostaglandin D2 (PGD2) is a naturally occurring substance that belongs to the prostaglandin family. It is derived from the metabolism of arachidonic acid by the enzyme prostaglandin D synthase. PGD2 is produced in several tissues throughout the body, including the brain, and is involved in various physiological processes.

PGD2 plays a crucial role in inflammation, pain, and immune responses. It acts as an important inflammatory mediator in mast cells, which are immune cells involved in allergic reactions and asthma. PGD2 promotes the recruitment and activation of other immune cells, leading to an amplified inflammatory response.

In addition to its role in inflammation, PGD2 is also involved in the regulation of sleep and wakefulness. It is known to induce sleep when administered intravenously, and its levels in the cerebrospinal fluid increase during sleep. This suggests that PGD2 is involved in the modulation of sleep cycles and circadian rhythm.

Chemical Composition:

Prostaglandin D2 is a lipid molecule composed of 20 carbon atoms, including a 5-membered ring structure and a carboxyl group. Its structure consists of a cyclopentane ring with two double bonds and a hydroxyl group. The molecule also contains various functional groups, such as an alcohol group and an ester group.

Uses and Applications:

  • Inflammation research: Prostaglandin D2 is utilized to investigate the mechanisms of inflammation and the role of mast cells in the inflammatory response. Researchers study its effects on immune cells and the release of pro-inflammatory mediators.
  • Pain research: PGD2 is employed to study the involvement of prostaglandins in pain signaling pathways. It helps researchers understand the role of PGD2 in nociception and the development of pain conditions.
  • Immune response research: The immune-modulating effects of PGD2 make it a valuable tool in exploring immune responses and immune disorders. It is used to study the activation and recruitment of immune cells, such as macrophages and T cells.
  • Sleep research: Prostaglandin D2's role in sleep regulation makes it an important tool in sleep research. Scientists investigate its effects on sleep architecture, sleep-wake cycles, and the regulation of circadian rhythm.

For more detailed information on the safe handling, storage, and disposal of Prostaglandin D2, please refer to the Material Safety Data Sheet (MSDS). Additional information, including related peer-reviewed papers, technical documents, and similar products, can be found at product code 538909.

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