PRIMA-1: A Powerful Antitumor Agent - Reactivate p53 and Induce Apoptosis

REF #: 3199511
Short description

PRIMA-1: A Powerful Antitumor Agent

  • A cell-permeable quinuclidinone analog with antitumor properties.
  • Increases the reactivation of p53 and induces massive apoptosis.
  • CAS Number: 5608-24-2
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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PRIMA-1: A Powerful Antitumor Agent

PRIMA-1 is a highly effective cell-permeable quinuclidinone analog that exhibits remarkable antitumor properties. Developed as a potent anticancer agent, PRIMA-1 has shown significant potential in reactivating the p53 tumor-suppressor protein and inducing massive apoptosis in cancer cells.

Key Information

  • CAS Number: 5608-24-2
  • Synonyms: PRIMA-1, 2, 2-Bis(hydroxymethyl)-1-azabicyclo[2, 2, 2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
  • Find Millipore-530050M MSDS, related peer-reviewed papers, technical documents, similar products & more at Millipore, 530050M


PRIMA-1 exhibits a unique chemical structure, characterized by a quinuclidinone backbone with additional hydroxymethyl groups. This composition contributes to its exceptional cell-permeability and bioavailability.


PRIMA-1 stands out among other antitumor agents due to its remarkable features:

  • Cell-Permeability: PRIMA-1 is able to efficiently penetrate the cell membrane, allowing it to exert its antitumor effects directly on cancer cells.
  • Tumor-Suppressor Reactivation: One of the key properties of PRIMA-1 is its ability to reactivate the p53 tumor-suppressor protein. p53 plays a pivotal role in controlling cell growth and preventing the proliferation of damaged cells, including cancer cells. By restoring the functionality of p53, PRIMA-1 unleashes a powerful defense mechanism against cancer.
  • Induction of Massive Apoptosis: PRIMA-1 triggers a process of massive apoptosis, or programmed cell death, in cancer cells. This mechanism is essential in eliminating abnormal or damaged cells, effectively inhibiting tumor growth and progression.


PRIMA-1 has shown great promise in various fields, particularly in cancer research and treatment. Some notable applications include:

  • Anticancer Drug Development: PRIMA-1 serves as a valuable tool in developing new anticancer drugs. Its ability to reactivate p53 and induce apoptosis provides a solid foundation for the design of targeted therapies.
  • Tumor-Suppressor Research: Scientists utilize PRIMA-1 to explore the mechanisms behind tumor suppression and the role of p53 in cancer development. Its reactivation of p53 allows for in-depth studies on the protein's functions and its potential as a therapeutic target.
  • Treatment Sensitization: PRIMA-1 has been investigated for its potential to sensitize cancer cells to conventional treatments such as chemotherapy and radiotherapy. By modulating p53 activity, PRIMA-1 can enhance the efficacy of existing therapies and overcome treatment resistance.

Safety Information

As with any potent chemical compound, it is important to handle PRIMA-1 with caution. Here are some safety considerations:

  • Storage: PRIMA-1 should be stored in a cool, dry place away from direct sunlight and moisture.
  • Handling: When working with PRIMA-1, it is recommended to wear appropriate protective equipment, including gloves and goggles, to minimize the risk of contact with skin, eyes, or inhalation.
  • Disposal: Dispose of PRIMA-1 in accordance with local regulations and guidelines for hazardous waste disposal.

PRIMA-1 is a powerful antitumor agent with the ability to reactivate the tumor-suppressor protein p53 and induce massive apoptosis in cancer cells. Its unique chemical composition and remarkable features make it a valuable tool in cancer research and treatment. Whether to enhance existing therapies or develop new anticancer drugs, PRIMA-1 is an invaluable asset in the fight against cancer.

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