Picrotoxinin (17617-45-7) - GABAA Receptor Antagonist for Neuroscience Research

REF #: 3199381
Short description

Picrotoxinin (17617-45-7) – GABAA Receptor Antagonist for Neuroscience Research

  • GABAA receptor antagonist: This compound acts as an antagonist for GABAA receptors.
  • Binds to the GABA receptor-linked Cl? channel: It binds specifically to the chloride channel linked to the GABA receptor.
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Picrotoxinin (17617-45-7) - GABAA Receptor Antagonist for Neuroscience Research

This compound is a featured product for Neuroscience research.

Key Features:

  • GABAA receptor antagonist
  • Binds to the GABA receptor-linked Cl? channel

Picrotoxinin (17617-45-7) is a naturally occurring compound commonly used in neuroscience research as a potent antagonist of GABA-A receptors. This compound plays a crucial role in investigating the function and mechanisms of GABA-A receptors, a subtype of inhibitory neurotransmitter receptors in the central nervous system. By binding to GABA-A receptors, picrotoxinin inhibits the actions of GABA, leading to an increase in neuronal excitability.

At a molecular level, picrotoxinin is composed of a complex structure with multiple functional groups. It has a molecular formula of C15H16O6 and a molecular weight of 304.28 g/mol. The compound consists of a bicyclic structure with a tetrahydrofuran ring fused to a cyclohexane ring, which contributes to its pharmacological activity and binding specificity.

Key Features:

  • GABAA receptor antagonist: Picrotoxinin acts as an antagonist at GABA-A receptors, inhibiting the actions of the inhibitory neurotransmitter GABA. This makes it an invaluable tool for studying the role of GABA and GABA receptors in various physiological and pathological processes.
  • Binds to the GABA receptor-linked Cl? channel: Picrotoxinin specifically binds to the chloride ion channel associated with the GABA-A receptor. By interacting with this binding site, picrotoxinin disrupts the normal flow of chloride ions, modulating the inhibitory signaling mediated by GABA.

In neuroscience research, picrotoxinin is widely used for various applications, including:

  • Investigating the role of GABAergic signaling in neuronal excitability and synaptic transmission.
  • Studying the effects of GABA-A receptor dysfunction in neurological disorders such as epilepsy, anxiety disorders, and sleep disorders.
  • Screening and evaluating potential GABAergic drugs and compounds for therapeutic purposes.
  • Examining the interactions between picrotoxinin and other ligands or modulators of GABA-A receptors.

When working with picrotoxinin, it is essential to follow proper handling and safety precautions. The compound should only be handled by trained personnel in a laboratory setting, adhering to established protocols and guidelines.

For detailed information about picrotoxinin and supplier details, please refer to the specific product code (P8390) provided by the supplier.

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