PF-03549184 - Potent Inhibitor of mPGES-1 for Inflammatory Conditions

REF #: 3199773
Procurenet
Short description

PF-03549184 (PF-9184) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It has a chemical name of N-(3′,4′-dichloro[1,1′-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and a product code of PZ0326. Its CAS number is 1221971-47-6.

  • Purity: 98% (HPLC)
  • Description: PF-03549184 is designed to inhibit the activity of mPGES-1, an enzyme involved in the production of prostaglandin E2, which plays a role in inflammation. By blocking this enzyme, PF-03549184 may have potential therapeutic applications in various inflammatory conditions.
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

PF-03549184

The PF-03549184 is a chemical compound with the chemical name N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. It is highly pure, with a purity of 98% as confirmed by High-Performance Liquid Chromatography (HPLC).

This compound, also known as PF-9184, is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). Prostaglandin E synthase-1 is an enzyme involved in the production of prostaglandin E2, which plays a key role in various physiological and pathological processes, including inflammation, pain, and fever. By inhibiting mPGES-1, PF-03549184 offers potential therapeutic benefits in the treatment of these conditions.

Features:

  • Target: Microsomal prostaglandin E synthase-1 (mPGES-1)
  • Type: Inhibitor
  • Potency: Potent
  • Purity: 98% (HPLC)

Product Information:

  • Product Code: PZ0326
  • CAS Number: 1221971-47-6

Composition:

  • N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Benefits and Applications:

  • Anti-inflammatory: As an inhibitor of mPGES-1, PF-03549184 has the potential to reduce inflammation, which is a common feature of various diseases and conditions.
  • Pain Relief: By targeting mPGES-1, PF-03549184 may help alleviate pain associated with inflammatory conditions.
  • Fever Reduction: Inhibition of mPGES-1 by PF-03549184 may contribute to the reduction of fever, a common symptom of inflammation.
  • Potential Therapeutic Agent: PF-03549184's ability to target mPGES-1 makes it a promising candidate for the development of novel therapeutics aimed at treating inflammation-related disorders.

Storage and Handling:

  • Store in a cool, dry place.
  • Avoid exposure to light and moisture.
  • Handle with appropriate protective measures, such as gloves and goggles.
  • Keep out of reach of children and pets.

PF-03549184 is a valuable chemical compound with potent inhibitory activity against mPGES-1. Its high purity, demonstrated by HPLC analysis, ensures its quality and reliability. With its potential anti-inflammatory, pain-relieving, and fever-reducing properties, PF-03549184 holds promise as a therapeutic agent for various inflammatory conditions. Its precise composition and strict storage guidelines make it a valuable tool for researchers and pharmaceutical companies working in the field of inflammation-related disorders.

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