PERK Inhibitor II GSK2656157 | Powerful Research Tool

REF #: 3199684
Procurenet
Short description
PERK Inhibitor II, GSK2656157
  • Synonyms: PERK Inhibitor II, GSK2656157, BRK Inhibitor II, EIF2AK1 Inhibitor II, EIF2AK2 Inhibitor III, EIF2AK3 Inhibitor II, HRI Inhibitor II, MEKK2 Inhibitor I, PKR Inhibitor III, PKR-like ER Kinase Inhibitor II
  • Product code: -504651
PERK Inhibitor II, GSK2656157 is a powerful inhibitor of PERK, BRK, EIF2AK1, EIF2AK2, EIF2AK3, HRI, MEKK2, PKR, and PKR-like ER Kinase. It is commonly used in research and scientific studies.
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

PERK Inhibitor II GSK2656157: A Versatile Inhibitor for Research and Scientific Studies

PERK Inhibitor II GSK2656157
Synonyms: PERK Inhibitor II, GSK2656157, BRK Inhibitor II, EIF2AK1 Inhibitor II, EIF2AK2 Inhibitor III, EIF2AK3 Inhibitor II, HRI Inhibitor II, MEKK2 Inhibitor I, PKR Inhibitor III, PKR-like ER Kinase Inhibitor II
Product Code: -504651

Introduction

PERK Inhibitor II GSK2656157 is a potent inhibitor that targets multiple protein kinases involved in the PERK signaling pathway. This versatile compound has gained significant attention for its ability to inhibit PERK (PRKR-like ER Kinase), BRK (Breast Tumor Kinase), EIF2AK1 (Eukaryotic translation initiation factor 2-alpha kinase 1), EIF2AK2 (Eukaryotic translation initiation factor 2-alpha kinase 2), EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3), HRI (Heme-regulated inhibitor), MEKK2 (MEK Kinase 2), PKR (Protein Kinase R), and PKR-like ER Kinase, making it a valuable tool for researchers exploring various cellular processes and disease pathways.

Composition and Features

PERK Inhibitor II GSK2656157 is a small molecule compound with a molecular formula of C13H10N6S2. It is a white to off-white crystalline powder that is soluble in dimethyl sulfoxide (DMSO) and methanol. The compound exhibits high purity and has been extensively characterized to ensure its quality and reliability.

Key features of PERK Inhibitor II GSK2656157:

  • Powerful inhibitor of PERK, BRK, EIF2AK1, EIF2AK2, EIF2AK3, HRI, MEKK2, PKR, and PKR-like ER Kinase
  • Wide range of applications in research and scientific studies
  • High purity and quality, ensuring consistent and reliable results
  • Chemically stable and available in a crystalline powder form
  • Soluble in dimethyl sulfoxide (DMSO) and methanol, allowing for easy preparation of stock solutions

Applications

PERK Inhibitor II GSK2656157 has found widespread use in diverse research areas, playing a crucial role in investigating the function of PERK signaling pathway and its implications in various cellular processes and disease pathogenesis. Some key applications include:

  • Studying endoplasmic reticulum (ER) stress response-mediated signaling pathways
  • Investigating the role of PERK in unfolded protein response (UPR)
  • Research on protein synthesis regulation and translation initiation
  • Exploring mechanisms of autophagy and apoptosis
  • Examining the involvement of PERK in cancer development and progression

Additionally, PERK Inhibitor II GSK2656157 has been employed in various preclinical studies and drug discovery programs aimed at identifying potential therapeutic targets and developing novel drugs to modulate PERK signaling for the treatment of diseases such as cancer, neurodegenerative disorders, and metabolic disorders.

Handling and Storage

Proper handling and storage of PERK Inhibitor II GSK2656157 are essential to maintain its stability and integrity. Here are some guidelines:

  • Store PERK Inhibitor II GSK2656157 at -20°C in a tightly sealed container, protected from light and moisture
  • Avoid repeated freeze-thaw cycles by storing aliquots to minimize degradation
  • Handle the compound with appropriate safety measures, including gloves and protective clothing
  • Prepare stock solutions of PERK Inhibitor II GSK2656157 in dimethyl sulfoxide (DMSO) or methanol at a concentration suitable for your experimental needs

Conclusion

PERK Inhibitor II GSK2656157 is a powerful and versatile tool for researchers studying PERK signaling pathway and its role in various physiological and pathological processes. Its inhibitory effects on multiple protein kinases make it a valuable compound in understanding the intricate signaling networks governing cellular responses such as ER stress, protein synthesis, autophagy, and apoptosis. With its high purity, stability, and easy solubility, PERK Inhibitor II GSK2656157 enables precise and reproducible experimentation, facilitating breakthrough discoveries in academic and industrial settings.

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