NOX Inhibitor IV GKT136901 - Highly Potent and Selective Inhibitor

REF #: 3199436
Procurenet
Short description

NOX Inhibitor IV, GKT136901

  • CAS Number: 955272-06-7
  • Synonyms: NOX Inhibitor IV, GKT136901, 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo-[4,3-c]pyridine-3,6(2H,5H)-dione, NADPH Oxidase Inhibitor IV, Dual NOX4/NOX1 Inhibitor, GKT-136901
  • MSDS: Available upon request
  • Related peer-reviewed papers: Numerous publications on the efficacy of NOX Inhibitor IV, GKT136901 in inhibiting NADPH oxidase activity
  • Technical documents: Comprehensive documentation on the usage and mechanism of NOX Inhibitor IV, GKT136901
  • Similar products: Explore other NOX inhibitors and related compounds
$0
Quantity :
  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
Delivery options
  • 7 Days Return Back Policy
  • 2 Days Cancellation Policy
  • Ship Only
Description

NOX Inhibitor IV, GKT136901

NOX Inhibitor IV, GKT136901 is a highly potent and selective inhibitor of NADPH oxidase, specifically targeting NOX4 and NOX1. Its chemical name is 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo-[4,3-c]pyridine-3,6(2H,5H)-dione. This compound has been extensively studied and has shown great promise as a therapeutic agent for various oxidative stress-related diseases.

Features and Benefits

  • Dual Inhibition: NOX Inhibitor IV, GKT136901 inhibits both NOX4 and NOX1 isoforms of NADPH oxidase, providing a comprehensive approach to oxidative stress management.
  • High Potency: GKT136901 is a highly potent inhibitor, effectively suppressing NADPH oxidase activity and reducing reactive oxygen species (ROS) production.
  • Selective: This inhibitor is highly selective for NOX4 and NOX1, sparing other isoforms of NADPH oxidase and minimizing off-target effects.
  • Broad Therapeutic Potential: GKT136901 has been shown to be effective in various disease models involving oxidative stress, including cardiovascular diseases, kidney diseases, and liver diseases.

Technical Information

CAS Number 955272-06-7
Synonyms NOX Inhibitor IV, GKT136901, 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo-[4,3-c]pyridine-3,6(2H,5H)-dione, NADPH Oxidase Inhibitor IV, Dual NOX4/NOX1 Inhibitor, GKT-136901
MSDS Available upon request

Applications

NOX Inhibitor IV, GKT136901 has a wide range of applications in both research and therapeutic areas. It has been extensively used in various studies and has shown efficacy in the following conditions:

  • Cardiovascular diseases
  • Kidney diseases
  • Liver diseases
  • Neurodegenerative diseases
  • Inflammatory diseases
  • Cancer

Mechanism of Action

NADPH oxidase plays a crucial role in the production of reactive oxygen species (ROS), which can cause oxidative damage to cells and tissues. NOX Inhibitor IV, GKT136901 acts as a potent and selective inhibitor of NOX4 and NOX1 isoforms, effectively blocking their activity and reducing ROS production.

By inhibiting NOX4 and NOX1, GKT136901 helps maintain redox homeostasis and protects cells from oxidative stress-related damage, offering potential therapeutic benefits in various disease conditions characterized by excessive ROS production.

Recommended Usage

The usage and dosage of NOX Inhibitor IV, GKT136901 may vary depending on the specific application and experimental setup. It is recommended to consult the provided technical documentation for detailed instructions on preparation, administration, and dosage.

For research purposes, GKT136901 can be dissolved in appropriate solvents such as DMSO or ethanol for in vitro studies. In vivo administration may require formulation in vehicle solutions suitable for the chosen route of administration.

It is essential to conduct a thorough evaluation of the compound's efficacy and safety profile in specific disease models or cell/tissue types prior to clinical translation.

Quality Control

NOX Inhibitor IV, GKT136901 is subjected to rigorous quality control procedures to ensure its purity, potency, and reliability. The following tests are carried out to meet the highest standards:

  • Chemical purity determination
  • Identity verification using spectroscopic techniques
  • Assessment of solubility and stability
  • Biological activity evaluation through in vitro assays

Related Products

Explore other NOX inhibitors and related compounds that may complement and enhance your research or therapeutic endeavors. Our extensive catalog includes:

  • NOX Inhibitor I
  • NOX Inhibitor II
  • NOX Inhibitor III
  • NOX Inhibitor V
  • NADPH Oxidase Substrate
  • ROS Detection Kits

For more information on these and other related products, please refer to our catalog or contact our support team.

All categories
Filters