NNNN-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) - Zinc Chelator for Apoptosis Research

REF #: 3199420
Short description

NNNN-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) is a zinc chelator widely used in Apoptosis research. It effectively permeates cell membranes, decreasing intracellular zinc levels. TPEN induces apoptosis, making it a reliable tool for studying cellular processes related to apoptosis.

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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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NNNN-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) - Zinc Chelator for Apoptosis Research

NNNN-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) is a compound that plays a crucial role in Apoptosis research. It is widely utilized as a zinc chelator and has the ability to penetrate cell membranes, thereby reducing intracellular zinc levels. This unique characteristic of TPEN makes it a valuable tool for investigating various cellular processes associated with apoptosis.


  • TPEN is a zinc chelator, enabling it to bind and sequester zinc ions within cells.
  • It exhibits the ability to permeate cell membranes, allowing it to access intracellular compartments.
  • The compound has been found to reduce intracellular zinc levels, which in turn can induce apoptosis.
  • TPEN is widely used in Apoptosis research as a reliable and effective tool.

Chemical Information:

The chemical name of TPEN is N,N,N,N-Tetrakis(2-pyridylmethyl)ethylenediamine. It is commonly referred to by its abbreviation TPEN.


TPEN's zinc chelation properties and ability to permeate cell membranes make it highly valuable for Apoptosis research. Some of the specific applications of TPEN include:

  • Studying the role of zinc in cellular processes related to apoptosis.
  • Investigating the impact of zinc depletion on cell viability and apoptosis induction.
  • Evaluating the mechanisms of zinc-dependent apoptotic signaling pathways.
  • Examining the relationship between intracellular zinc levels and overall cellular homeostasis.


TPEN is an organic compound with the chemical formula C24H28N4. Its structure consists of four pyridylmethyl groups attached to an ethylenediamine backbone. The compound's unique structure allows it to effectively chelate zinc ions and penetrate cell membranes.

Safety Information:

When working with TPEN, it is important to follow the necessary safety precautions to ensure the well-being of individuals and the environment:

  • Use TPEN in a well-ventilated area or under a fume hood to prevent inhalation of the compound.
  • Wear appropriate personal protective equipment (PPE), including gloves and safety glasses, when handling TPEN.
  • Avoid direct skin contact with TPEN. In case of contact, wash the affected area thoroughly with soap and water.
  • Dispose of TPEN and any contaminated materials according to local regulations.

Disclaimer: The information provided here is for informational purposes only. It is the responsibility of the user to ensure compliance with all applicable laws and regulations regarding the use and handling of TPEN. This product should be handled only by trained professionals.

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