HPI-4 (Ciliobrevin A) - Highly Purified Hedgehog Pathway Inhibitor

REF #: 3199565
Procurenet
Short description

HPI-4 (Ciliobrevin A) is a highly purified Hedgehog pathway inhibitor that is >= 98% HPLC purity. This chemical compound inhibits dynein ATPase in Leishmania and acts as a hedgehog pathway inhibitor and ciliogenesis inhibitor. Its chemical name is 2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-u0152u2264-oxo-benzenepropanenitrile (CAS Number: 302803-72-1), also known as H4541 or Hedgehog Pathway Inhibitor 4.

$0
Quantity :
  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
Delivery options
  • 7 Days Return Back Policy
  • 2 Days Cancellation Policy
  • Ship Only
Description

HPI-4 (Ciliobrevin A) is a highly purified compound with a minimum HPLC purity of 98%. It is a powerful Hedgehog pathway inhibitor (HP1-4) that has shown great potential in various research applications. With its unique mechanism of action, HPI-4 effectively inhibits dynein ATPase in Leishmania, offering valuable insights into the molecular pathways involved in this disease.

The Hedgehog pathway is a highly conserved signaling pathway that plays a critical role in embryonic development and tissue homeostasis. Dysregulation of this pathway has been implicated in the development of several types of cancers and other diseases. HPI-4 acts as a potent inhibitor of this pathway, making it an invaluable tool for researchers investigating cellular processes regulated by Hedgehog signaling.

One of the key features of HPI-4 is its ability to inhibit ciliogenesis. Cilia are microtubule-based organelles found on the surface of most mammalian cells. They play crucial roles in cell signaling, motility, and sensory functions. HPI-4 specifically targets the formation of primary cilia, making it an excellent tool for studying ciliogenesis and its associated diseases.

The chemical name of HPI-4 is 2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-u0152u2264-oxo-benzenepropanenitrile. It has a unique molecular structure that contributes to its potent inhibitory activity. The CAS number for HPI-4 is 302803-72-1, which serves as a unique identifier for this compound.

Key Features:

  • Purity: HPI-4 is highly purified with a minimum HPLC purity of 98%, ensuring reliable and reproducible results in research experiments.
  • Hedgehog Pathway Inhibitor: HPI-4 is a powerful inhibitor of the Hedgehog signaling pathway, helping researchers dissect the intricate signaling events involved in development and disease.
  • Inhibits Dynein ATPase in Leishmania: HPI-4 has been shown to effectively inhibit dynein ATPase in Leishmania, providing valuable insights into the molecular mechanisms underlying this parasitic disease.
  • Ciliogenesis Inhibitor: HPI-4 specifically targets the formation of primary cilia, making it a valuable tool for studying ciliogenesis and associated diseases.
  • Alternate Names: HPI-4 is also known as H4541 and Hedgehog Pathway Inhibitor 4, providing various options for referencing and searching.

In conclusion, HPI-4 (Ciliobrevin A) is a highly purified Hedgehog pathway inhibitor with a minimum HPLC purity of 98%. It is a potent inhibitor of dynein ATPase in Leishmania and effectively inhibits ciliogenesis. With its unique chemical structure and molecular properties, HPI-4 is an exceptional tool for researchers investigating the Hedgehog signaling pathway, ciliogenesis, and related diseases.

All categories
Filters