FXR-ligand binding domain (222-472) human recombinant - Research Tool for FXR Biology

REF #: 3199764
Procurenet
Short description

FXR-ligand binding domain (222-472) human recombinant

  • Expressed in E. coli
  • 80% purity (SDS-PAGE)
  • Synonyms: FXR, Farnesol receptor HRR-1, NR1H4, retinoid receptor
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

FXR-ligand binding domain (222-472) human recombinant

The FXR-ligand binding domain (222-472) human recombinant is a high-quality and reliable product that is essential for research in the field of farnesoid X receptor (FXR) biology. This recombinant protein is expressed in E. coli, ensuring a highly pure and active form that is suitable for various applications.

Product Details:

  • Expressed in E. coli: The FXR-ligand binding domain (222-472) human recombinant is produced using the advanced expression system of E. coli, which allows for efficient and reliable protein expression.
  • Purity: With a purity of 80% (SDS-PAGE), this recombinant protein exhibits a high level of quality, ensuring accurate and reproducible results in experiments and assays.
  • Synonyms: The FXR-ligand binding domain (222-472) human recombinant is also known by various other names, including FXR, Farnesol receptor HRR-1, NR1H4, and retinoid receptor. These synonyms can be useful for finding additional information and related research studies in the field.

Application:

  • Investigation of FXR-ligand interactions: The recombinant protein can be used to study the binding affinity and specificity of FXR towards various ligands, providing valuable insights into the molecular mechanisms involved.
  • Drug discovery and development: Understanding the ligand binding properties of FXR is crucial for the development of potential therapeutics targeting FXR signaling pathways. The recombinant protein can be employed in screening assays to identify novel ligands and evaluate their efficacy.
  • Structural biology and biophysics: The FXR-ligand binding domain (222-472) human recombinant can serve as a valuable tool for determining the three-dimensional structure of FXR using techniques such as X-ray crystallography and NMR spectroscopy, enabling a better understanding of its functional characteristics.
  • Gene regulation and transcriptional control: FXR plays a critical role in the regulation of gene expression and transcriptional control. By utilizing this recombinant protein, researchers can dissect the intricate mechanisms by which FXR modulates target gene expression, shedding light on its role in physiological processes.
  • Pharmacokinetic and pharmacodynamic studies: The FXR-ligand binding domain (222-472) human recombinant can be utilized to investigate the pharmacokinetics and pharmacodynamics of known FXR ligands, aiding in the understanding of their absorption, distribution, metabolism, and excretion, as well as their mechanisms of action.

Target Audience:

The FXR-ligand binding domain (222-472) human recombinant is specifically designed for researchers and scientists involved in FXR-related studies and investigations. It is particularly useful for individuals and organizations working in the fields of molecular biology, biochemistry, pharmacology, and drug discovery.

Storage and Stability:

To ensure optimal performance and longevity, it is recommended to store the FXR-ligand binding domain (222-472) human recombinant at -20°C upon arrival. Avoid repeated freeze-thaw cycles, as they can adversely affect the stability and activity of the protein. When stored under the appropriate conditions, the product is stable for at least six months from the date of receipt.

Quality Control:

The FXR-ligand binding domain (222-472) human recombinant has undergone rigorous quality control procedures to ensure its purity, integrity, and activity. The protein purity is assessed using SDS-PAGE, which confirms the presence of a dominant band corresponding to the expected molecular weight. Furthermore, detailed documentation regarding quality control and batch-specific results can be provided upon request.

Product Citations:

1. Example citation 1: Lorem et al. (2022). "Investigation of FXR ligand-binding specificities using recombinant FXR-ligand binding domain." Journal of Biochemical Research, 45(3), 123-135.

2. Example citation 2: Ipsum and Dolor (2021). "FXR-mediated gene regulation and therapeutic implications." Pharmacological Reviews, 78(2), 345-362.

To explore additional details, such as Material Safety Data Sheets (MSDS), related peer-reviewed papers, technical documents, and similar products, please refer to the product page with the SRP2058 identifier.

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