Enflicoxib - Highly Effective and Selective COX-2 Inhibitor

REF #: 3199583
Short description

Enflicoxib is a highly effective and selective cyclooxygenase 2 (COX-2) inhibitor. It is orally available and can be stored at temperatures ranging from -10 to -25°C. The compound is soluble in DMSO at 2 mg/mL.

  • Product Name: Enflicoxib
  • CAS Number: 251442-94-1
  • Chemical Formula: C15H10F6N4O2S
  • Molecular Weight: 434.32 g/mol
  • Physical State: Solid
  • Storage Conditions: -10 to -25°C
  • Category: [selected categories]
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Enflicoxib is a highly effective and selective oral medication that falls under the category of cyclooxygenase 2 (COX-2) inhibitors. This class of drugs inhibits the action of the COX-2 enzyme, which is responsible for the production of prostaglandins, a type of chemical messenger that triggers inflammation and pain.

Enflicoxib is known for its potent and specific inhibitory activity against the COX-2 enzyme. This selectivity makes it an ideal therapeutic option for managing pain and inflammation, particularly in conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders.

One of the notable characteristics of Enflicoxib is its stability under specific storage conditions. It is recommended to store Enflicoxib at temperatures ranging from -10 to -25°C. This temperature range ensures optimal preservation and maintenance of its chemical properties for an extended shelf life.

In terms of solubility, Enflicoxib readily dissolves in dimethyl sulfoxide (DMSO) at a concentration of 2 mg/mL. This solubility profile allows for convenient and efficient preparation of Enflicoxib solutions for various laboratory applications.

Product Details:

  • Product Name: Enflicoxib
  • Chemical Formula: C16H10F6N4O2S
  • CAS Number: 251442-94-1
  • Alternate Names: (±)-E 6087, 1-(4-aminosulphonylphenyl)-5-(2, 4-difluorophenyl)-4, 5-dihydro-3-trifluoromethyl-1H-pyrazole, 4-(5-(2, 4-difluorophenyl)-3-(trifluoromethyl)-4, 5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Main Features:

  • Potent Inhibition: Enflicoxib is a highly potent and selective COX-2 inhibitor, effectively reducing production of pro-inflammatory prostaglandins.
  • Oral Availability: Enflicoxib is designed for oral administration, providing convenient and versatile dosing options for patients.
  • Management of Inflammation: By targeting the COX-2 enzyme, Enflicoxib effectively manages inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis.
  • Pain Relief: Enflicoxib's inhibitory action on prostaglandin synthesis helps alleviate pain, making it a valuable option for pain management.
  • Stability: Enflicoxib is stable under recommended storage conditions, ensuring a longer shelf life and consistent quality.
  • Solubility: Enflicoxib exhibits high solubility in DMSO, facilitating preparation of solutions for laboratory applications.

Enflicoxib, also known as (±)-E 6087, possesses a unique chemical structure consisting of a 5-member pyrazole ring fused with a benzene sulfonamide moiety. This distinct structure contributes to its selective inhibition of the COX-2 enzyme.

Enflicoxib has demonstrated significant effectiveness in preclinical and clinical studies, highlighting its potential as an important therapeutic agent for managing pain and inflammation. Its selectivity for COX-2 inhibition reduces the risk of unwanted side effects commonly associated with non-selective COX inhibitors.

As with any medication, Enflicoxib should be used under the guidance and prescription of a qualified healthcare professional. The recommended dosage and duration of treatment may vary depending on the specific condition being treated and individual patient factors.

In summary, Enflicoxib is a highly potent and selective COX-2 inhibitor with significant therapeutic potential. Its oral availability, stability under recommended storage conditions, and solubility in DMSO make it a valuable tool for laboratory research and a promising option for managing pain and inflammation in various medical conditions.

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