Creatine Phosphate Sodium for Injection: Myocardial Protection and More
ProcurenetShort description
Injectable Creatine Phosphate Sodium is an effective medicinal compound used in cardio-surgery for myocardial protection, with efficient treatment of metabolic abnormalities caused by ischemia. Its molecular formula is C4H8N3O5PNa2 and it has a molecular weight of 327.13. This medical product functions by donating a phosphate group to ADP to form ATP in high energy demand situations such as during intense muscular or neuronal effort. It is safe to administer with no known contraindications, though caution should be observed in patients with chronic renal insufficiency and among those likely to react to high intake of phosphate sodium.
- Grade: Injection
- Usage and Dosage: 1.0g 1-2 times daily via intravenous injection within 30-45 mins
- Contraindications: Allergy to creatine phosphate, chronic renal insufficiency
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Procurenet Team Tshim Sha Tsui
Hong Kong
3 years
Description
Creatine Phosphate Sodium for Injection
Creatine Phosphate Sodium is a highly efficacious medication used primarily for myocardial protection. Scientifically recognized as N-[Imino(phosphonoamino)methyl] -N-methylglycine, this white or crystalline powder has a molecular formula of C4H8N3O5PNa2u00b74H2O and a molecular weight of 327.13.
Key Features:
- Prescribed dosage: 1.0g, 1-2 times daily via intravenous injection administered in 30-45 minutes.
- Applicable in cardiopulmonary bypass with a concentration of 10 mmol/L for myocardial protection.
- No known contraindications, making it a safe option.
- Chance of decreased blood pressure with rapid injection speed exceeding 1.0g.
- High intake of phosphate sodium caused by large dose (5-10g/day) may affect calcium metabolism and stable state hormone secretion.
- Adverse reactions are rare; in case of discomfort, consult a healthcare professional immediately.
- Patients with chronic renal insufficiency or known allergy to creatine phosphate should avoid usage.
Clinical Pharmacology:
In an anaerobic environment, Phosphocreatine can donate a phosphate group to ADP to form ATP during intense muscular or neuronal effort. Regulated by several creatine kinases, this reversible phosphorylation is crucial in tissues facing high and variable energy demands like muscles and brain.
Pharmacokinetics:
Following intramuscular injection, the drug concentration peaks within 20-40 minutes. Intravenously, the active form of creatine phosphate gradually diminishes within 30 minutes. Intramuscular injection results in an average half-life (T1/2) of 0.09-0.12 hours in humans.
Additional Information:
Beyond its therapeutic effects, Creatine Phosphate Sodium has achieved widespread acceptance due to its reliable safety profile, leading to significant global usage.
Re-establishing metabolic normalcy in ischemically challenged myocardium has also been an appreciable effect of this medication. All these factors contribute to the overall appeal for Creatine Phosphate Sodium in the medical field.
