Clobazam - Potent Anxiolytic Compound for Anxiety Disorders

REF #: 3199683
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Short description
  • Clobazam – Potent Anxiolytic Compound for Anxiety Disorders
  • Chemical Name: 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
  • Anxiolytic properties
  • Ligand for the GABAA receptor benzodiazepine modulatory site
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

Clobazam - Potent Anxiolytic Compound for Anxiety Disorders

  • Clobazam is a highly effective anxiolytic compound widely known for its calming effects.
  • It belongs to the class of benzodiazepines and acts as a positive allosteric modulator of the GABA receptor.
  • Used in the management of anxiety disorders including generalized anxiety disorder, panic disorder, and social anxiety disorder.
  • Also found to be helpful in the treatment of insomnia, muscle spasms, and epilepsy.

Chemical Properties of Clobazam

  • Chemical Name: 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
  • CAS Number: 22316-47-8
  • Molecular Formula: C16H13ClN2O2
  • Molecular Weight: 300.74 g/mol
  • Systematic Name: 7-chloro-1-methyl-5-phenyl-2,4-dihydro-1H-1,5-benzodiazepine-2,4-dione

Applications of Clobazam

  • Primary anxiolytic agent for the management of anxiety disorders.
  • Effective in the treatment of generalized anxiety disorder (GAD), panic disorder, and social anxiety disorder (SAD).
  • Alleviates symptoms associated with insomnia, muscle spasms, and epilepsy.

Mechanism of Action

  • Acts as a positive allosteric modulator of the GABA receptor.
  • Enhances inhibitory transmission by increasing the effect of the inhibitory neurotransmitter GABA.
  • Results in sedative, anxiolytic, and anticonvulsant effects.

Safety and Precautions

  • Should be used under the guidance of a healthcare professional.
  • Adhere to the prescribed dosage and treatment duration.
  • Abrupt discontinuation can cause withdrawal symptoms.
  • May cause drowsiness and impair cognitive and motor functions.
  • Avoid activities requiring mental alertness.
  • Not recommended for individuals with a history of drug or alcohol abuse.
  • Dosage adjustments may be necessary for individuals with liver or kidney disease or concurrent medical conditions.
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