API-1 (4-Amino-58-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[23-d]pyrimidine-6-carboxamide) - Akt/PKB Inhibitor

REF #: 3199854
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Short description

API-1 (4-Amino-58-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[23-d]pyrimidine-6-carboxamide) – Akt/PKB Inhibitor

  • Powerful inhibitor: API-1 is a potent and specific Akt/PKB inhibitor
  • Product code: SML1342
  • Chemical name: 4-Amino-5, 8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2, 3-d]pyrimidine-6-carboxamide
  • Alternate names: NSC 177223, NSC177223
  • CAS number: 36707-00-3
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  • Procurenet Team Tshim Sha Tsui
    Hong Kong Hong Kong 3 years
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Description

API-1 (4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide) - Akt/PKB Inhibitor

API-1 is a potent and specific Akt/PKB inhibitor that is commonly used in various research applications. Also known as SML1342, NSC 177223, NSC177223, and by its chemical name, 4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide, this compound plays a crucial role in the field of biochemistry and medicinal chemistry.

Product Features:

  • Potent and specific Akt/PKB inhibitor
  • Used in various research applications
  • Chemical formula: C14H18N6O4
  • Molecular weight: 342.33 g/mol

Product Details:

API-1, also known as 4-Amino-5,8-dihydro-5-oxo-8-b-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide, is a highly specific Akt/PKB inhibitor. It is commonly utilized in scientific research to study the Akt/PKB signaling pathway and its involvement in cellular processes such as cell growth, survival, and metabolism.

Supplied as a pure, white to off-white powder, API-1 should be stored in a dry and cool place, away from sources of heat and direct sunlight. To ensure safety, it is important to handle API-1 with proper protective equipment, such as gloves and goggles.

Usage and Applications:

API-1 is primarily used as a research tool in the field of biochemistry and medicinal chemistry. It plays a significant role in investigating the Akt/PKB pathway and its implications in various biological processes and diseases, including cancer, diabetes, and neurodegenerative disorders.

Some specific applications of API-1 include:

  • Studying the signaling mechanisms of the Akt/PKB pathway
  • Investigating the effects of Akt/PKB inhibition on cellular processes
  • Exploring the potential therapeutic benefits of targeting the Akt/PKB pathway
  • Screening and identification of novel inhibitors for Akt/PKB
  • Enhancing the understanding of molecular interactions associated with Akt/PKB

Handling and Safety:

When working with API-1, it is crucial to follow proper safety protocols to ensure the well-being of laboratory personnel and prevent potential hazards. The compound should be handled with care and stored appropriately to maintain its stability and effectiveness.

Safety precautions when handling API-1:

  • Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat
  • Avoid contact with skin, eyes, and clothing
  • Handle in a well-ventilated area or under a fume hood to prevent inhalation of dust or vapors
  • Do not ingest or swallow the compound
  • Store in a cool, dry place away from heat and direct sunlight

In case of accidental exposure or ingestion, seek immediate medical attention and provide the necessary safety data sheets and product information.

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