AICA-Riboside: Activator of AMPK and Regulator of Purine Synthesis

REF #: 3199466
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Short description

AICA-Riboside: Activator of AMPK and Regulator of Purine Synthesis

  • CAS Number: 2627-69-2
  • Synonyms: AICA-Riboside, Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, Z-Riboside, AMPK Signaling Activator II
  • Properties: cell-permeable, phosphorylated metabolite
  • Function: activates AMPK, regulates de novo purine synthesis
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Description

AICA-Riboside: Activator of AMPK and Regulator of Purine Synthesis

AICA-Riboside is a highly effective cell-permeable nucleoside compound that has been widely studied for its ability to activate adenosine monophosphate-activated protein kinase (AMPK) and regulate de novo purine synthesis. With its unique properties and well-documented biological functions, AICA-Riboside has become a valuable tool in various research fields.

CAS Number

2627-69-2

Synonyms

AICA-Riboside, Acadesine, AICAr, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, Z-Riboside, AMPK Signaling Activator II

Properties

  • Cell-permeable: AICA-Riboside has the ability to easily cross cell membranes, allowing it to efficiently reach its target within cells.
  • Phosphorylated metabolite: Once inside the cells, AICA-Riboside is rapidly phosphorylated, leading to the formation of AICA-Ribotide (ZMP), a potent activator of AMPK.

Function

AICA-Riboside is known for its dual function as an activator of AMPK and a regulator of de novo purine synthesis, making it a versatile compound with broad implications in cellular metabolism and energy homeostasis.

  • Activates AMPK: AICA-Riboside binds to the γ-subunit of AMPK, leading to conformational changes that facilitate the phosphorylation of AMPK and subsequent activation. Once activated, AMPK plays a crucial role in cellular energy sensing, metabolism, and survival.
  • Regulates de novo purine synthesis: AICA-Riboside inhibits the enzyme phosphoribosylformylglycinamidine synthase (PFAS), which is involved in the de novo synthesis of purine nucleotides. By inhibiting PFAS, AICA-Riboside decreases the production of purine nucleotides and leads to metabolic shifts that can have broad implications in cellular processes.

Research has demonstrated the potential of AICA-Riboside in various fields:

  • Metabolic disorders: AICA-Riboside has been investigated for its potential in treating metabolic disorders such as obesity, type 2 diabetes, and insulin resistance. Activation of AMPK by AICA-Riboside promotes glucose uptake and fatty acid oxidation, leading to improved metabolic profiles.
  • Cancer research: AMPK activation by AICA-Riboside has shown promising effects in inhibiting cancer cell growth and inducing apoptosis. AICA-Riboside has been studied in various cancer types, including breast cancer, prostate cancer, and colorectal cancer.
  • Neuroprotection: AICA-Riboside has been found to have neuroprotective properties in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Activation of AMPK by AICA-Riboside has been shown to enhance neuronal survival and protect against oxidative stress.

Overall, AICA-Riboside is a potent and versatile compound that offers researchers a valuable tool for studying cellular metabolism, energy homeostasis, and various disease processes. Its ability to activate AMPK and regulate de novo purine synthesis makes it an attractive molecule for understanding and potentially targeting metabolic disorders, cancer, and neurodegenerative diseases.

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