5-Aza-2-Deoxycytidine (Decitabine) - Powerful Demethylating Agent for Cancer Treatment

REF #: 3199626
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Short description

5-Aza-2-Deoxycytidine (Decitabine) – Powerful Demethylating Agent for Cancer Treatment

  • CAS Number: 2353-33-5
  • Purity: ≥ 97%
  • Chemical Formula: C8H12N4O4
  • Molecular Weight: 228.21
  • Description: 5-Aza-2-Deoxycytidine is a demethylating agent with potential anticancer activity. It inhibits DNA methyltransferase, leading to DNA hypomethylation and reactivation of tumor suppressor genes. This compound has been extensively studied in breast cancer cell lines, chromatin, DNA, and the promoter region of the p16 gene. It is commonly used in epigenetic therapy for various cancers.
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Description

5-Aza-2-Deoxycytidine (Decitabine) - Powerful Demethylating Agent for Cancer Treatment

  • CAS Number: 2353-33-5
  • Purity: ≥ 97%
  • Chemical Formula: C8H12N4O4
  • Molecular Weight: 228.21

Description

5-Aza-2-Deoxycytidine, also known as Decitabine, is a powerful demethylating agent used in cancer treatment. This compound has garnered significant attention in the field of epigenetic therapy, with its mechanism of action showing potential for the reactivation of tumor suppressor genes through DNA hypomethylation. Its promising results in breast cancer cell lines, chromatin, DNA, and the promoter region of the p16 gene have made it a widely studied and used drug in the treatment of various cancers.

Features

  • Demethylating agent with potential anticancer activity
  • Inhibits DNA methyltransferase
  • Leads to DNA hypomethylation
  • Reactivates tumor suppressor genes
  • Extensively studied in breast cancer cell lines
  • Investigated in chromatin, DNA, and the promoter region of the p16 gene
  • Commonly used in epigenetic therapy for various cancers

Detailed Information

5-Aza-2-Deoxycytidine, also known as Decitabine, is a chemical compound with the molecular formula C8H12N4O4 and a molecular weight of 228.21. It is classified as a demethylating agent and has shown potential anticancer activity through its ability to inhibit DNA methyltransferase.

One of the primary mechanisms of action of 5-Aza-2-Deoxycytidine is its ability to induce DNA hypomethylation. By inhibiting DNA methyltransferase, the compound prevents the addition of methyl groups to DNA molecules, resulting in a decrease in overall DNA methylation levels. This reduction in DNA methylation has been linked to the reactivation of tumor suppressor genes, which are commonly silenced in cancer cells.

The demethylating activity of 5-Aza-2-Deoxycytidine has been extensively studied in various cancer models, particularly in breast cancer cell lines. Through its ability to restore the expression of tumor suppressor genes, it has shown promise in inhibiting the growth and survival of cancer cells.

Additionally, 5-Aza-2-Deoxycytidine has been investigated in the context of chromatin and DNA modifications. Studies have shown that it can induce changes in chromatin structure, leading to the opening of previously inaccessible regions of the DNA and allowing for gene expression. This effect on chromatin remodeling further contributes to the reactivation of tumor suppressor genes and the inhibition of cancer cell proliferation.

Furthermore, research has focused on the effects of 5-Aza-2-Deoxycytidine on the promoter region of the p16 gene, a well-known tumor suppressor gene. By targeting the methylation status of the p16 promoter, this compound has demonstrated the ability to restore p16 gene expression, leading to the suppression of cancer cell growth.

Due to its potent demethylating activity and its potential to reactivate tumor suppressor genes, 5-Aza-2-Deoxycytidine is commonly used in epigenetic therapy for various cancers. Clinical trials have shown promising results in the treatment of hematological malignancies, such as acute myeloid leukemia and myelodysplastic syndromes.

Overall, 5-Aza-2-Deoxycytidine, or Decitabine, is a powerful demethylating agent with potential anticancer activity. Through its inhibition of DNA methyltransferase and subsequent DNA hypomethylation, it reactivates tumor suppressor genes and shows promise in epigenetic therapy for various cancers.

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