1-Aminobenzotriazole (ABT) - Cytochrome P450 Inhibitor for Studying Estrogen Effects

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1-Aminobenzotriazole (ABT) – Cytochrome P450 Inhibitor for Studying Estrogen Effects

  • Chemical Formula: C6H6N4
  • Molecular Weight: 134.14 g/mol
  • CAS Number: 1614-12-6
  • Synonyms: ABT, 1-Benzotriazolamine
  • Ideal for investigating the effects of estrogen
  • Can be used in studies related to H2O2-induced premature senescence of vascular smooth muscle cells from old rats

1-Aminobenzotriazole (ABT) is a potent cytochrome P450 inhibitor that finds applications in various research areas. It is particularly useful for studying the effects of estrogen on biological processes such as premature senescence of vascular smooth muscle cells. With its precise chemical formula and molecular weight, ABT provides reliable and reproducible results in experiments. Its CAS Number and synonyms are widely recognized in the scientific community.

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Description

1-Aminobenzotriazole (ABT) - Cytochrome P450 Inhibitor for Studying Estrogen Effects

1-Aminobenzotriazole (ABT) is a versatile chemical compound widely used as a potent cytochrome P450 inhibitor in scientific research. With its extensive applications in investigating the effects of estrogen, inhibiting cytochrome P450 enzymes, and organic synthesis, ABT proves to be an indispensable tool in various industries and research fields.

Key Features:

  • Chemical Formula: C6H6N4
  • Molecular Weight: 134.14 g/mol
  • CAS Number: 1614-12-6
  • Synonyms: ABT, 1-Benzotriazolamine
  • Appearance: White crystalline solid
  • Melting Point: 127-130°C
  • Solubility: ABT is soluble in water, methanol, ethanol, and other common organic solvents. It shows low solubility in non-polar solvents.
  • Stability: ABT is stable under normal storage and handling conditions. It should be stored in a cool, dry place away from oxidizing agents.

Applications:

  • Investigating the Effects of Estrogen: ABT is commonly employed in studies to explore the impact of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells derived from older rats. By inhibiting cytochrome P450, ABT enables researchers to examine the specific role of estrogen in cellular senescence, providing important insights into age-related diseases and potential therapeutic interventions.
  • Cytochrome P450 Inhibition: ABT exhibits strong inhibitory properties against various isoforms of cytochrome P450, making it an invaluable tool for pharmaceutical research and drug discovery. Its inhibition of cytochrome P450 enzymes allows for the investigation of metabolic pathways, drug-drug interactions, and the identification of potential drug targets.
  • Organic Synthesis: ABT is also used in organic synthesis as a reagent or catalyst in various reactions. Its unique structural properties make it a valuable building block in the synthesis of heterocyclic compounds and other organic molecules.
  • Photographic Development: ABT is utilized in photographic development processes as a silver halide activator and stabilizer. Its ability to enhance the development of silver halide crystals plays a crucial role in achieving high-quality photographic prints.

Handling and Safety:

  • Use appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles when handling ABT.
  • Avoid inhalation or contact with skin and eyes. In case of contact, rinse thoroughly with water and seek medical attention if necessary.
  • Ensure proper ventilation in the working area to prevent the build-up of potentially harmful vapors.
  • Store ABT in a tightly sealed container away from heat, sparks, and open flames as it may be flammable.
  • Dispose of ABT and its waste according to local regulations and guidelines.

1-Aminobenzotriazole (ABT) is a highly valuable chemical compound widely used as a cytochrome P450 inhibitor in scientific research. Its diverse applications in studying the effects of estrogen, inhibiting cytochrome P450 enzymes, and organic synthesis make it an indispensable tool in various industries and research fields. With its stable properties and well-established safety guidelines, ABT ensures reliable and safe experimentation for researchers worldwide.

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